The addition of the hormone progesterone to gender-affirming hormone therapy leads to increased breast growth for transgender people following feminising hormone therapy.

Our results show that progesterone is safe and effective for transgender people. We’re now able to prescribe it, in a trial setting, for those who have been taking oestradiol for at least year. We hope that our findings lead to better hormone treatments for transgender individuals." Koen Dreijerink, endocrinologist at Amsterdam UMC

  • Leesi@lemmy.blahaj.zone
    2·
    3 months ago

    This post and comment reminds me of something I’ve been wondering about and maybe can get an answer on from someone here.

    I notice more tenderness in my breasts when I take oestradiol sublingually all at once rather than spread out over the day. Usually at night and tenderness comes the following evening. I’ve been taking it to mean that this regimen is better for my breast growth. I figure because it more naturally mimics the fluctuating levels cis women have iirc.

    I also notice that at larger dosages help, but with too large dosages this effect goes away. I know that more does not always mean better when it comes to pharmaceuticals, and have wondered if perhaps slightly less than adult/maximal oestrogen levels (but not low or underdosed) with completely suppressed T mimics puberty closer and is more conductive to breast growth?

    The tenderness hits even harder for a while if I switch to spread-out dosing for a while and then go back to all-at-once.

    I may be wrong in every one of those assumptions, but the point of me asking is to figure that out. Does anyone know more?

    1. Does this tenderness actually indicate breast growth and am I right to try to maximize it?
    2. I have heard progesterone finishes off the last stages breast development, which is why I’ve been putting it off and letting them grow as much as possible. Is this correct? Is it possible to wait too long?
    3. Are there any studies on, or reliable methods for maximizing breast growth during transition?

    Any help appreciated. Thanks