If we’re just talking voyager, it’s “Delete the wife”. If we’re talking all of trek, it might be “Hey Worf, Eat any good books lately?”
“Computer, deactivate iguana.”
“eat any good books lately?”
“You know, I’m really easy to get along with - most of the time - but I don’t like bullies, and I don’t like threats - and I don’t like you”
Edit: A close second is “Survival is insufficient”
“do not confuse composure with ease” is one I quote a lot. It’s not easy being broken but I learned to be composed about it so nobody can see it
“I hate temporal mechanics”
And
“He was more than a hero. He was a union man!”
“Gentlemen, I suggest you beam me aboard.”
-TOS: The Doomsday Machine
Runner-up quote: “This is highly improbable.”
-TNG: Cause and Effect
Tom : “What do you think? Boy or a girl?” Seven : “It’s a holographic projection.”
Probably the grocery store line, but I’m a chatty fellow.
“I know”



